NFAT1 transcription factor regulates cell cycle progression and cyclin E expression in B lymphocytes.

ABSTRACT: The NFAT family of transcription factors has been primarily related to T cell development, activation, and differentiation. Further studies have shown that these ubiquitous proteins are observed in many cell types inside and outside the immune system, and are involved in several biological processes, including tumor growth, angiogenesis, and invasiveness. However, the specific role of the NFAT1 family member in naive B cell proliferation remains elusive. Here, we demonstrate that NFAT1 transcription factor controls Cyclin E expression, cell proliferation, and tumor growth in vivo. Specifically, we show that inducible expression of NFAT1 inhibits cell cycle progression, reduces colony formation, and controls tumor growth in nude mice. We also demonstrate that NFAT1-deficient naive B lymphoc

SUBMITTER: Teixeira LK 

PROVIDER: S-EPMC5004684 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature