Syndecan-4 Signaling Is Required for Exercise-Induced Cardiac Hypertrophy.

ABSTRACT: Cardiac hypertrophy can be broadly classified as either physiological or pathological. Physiological stimuli such as exercise cause adaptive cardiac hypertrophy and normal heart function. Pathological stimuli including hypertension and aortic valvular stenosis cause maladaptive cardiac remodeling and ultimately heart failure. Syndecan-4 (synd4) is a transmembrane proteoglycan identified as being involved in cardiac adaptation after injury, but whether it takes part in physiological cardiac hypertrophy is unclear. We observed upregulation of synd4 in exercise-induced hypertrophic myocardium. To evaluate the role of synd4 in the physiological form of cardiac hypertrophy, mice lacking synd4 (synd4^-/-) were exercised by swimming for 4 wks. Ultrasonic cardiogram (UCG) and histologica

SUBMITTER: Xie J 

PROVIDER: S-EPMC5004706 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature