Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype.

ABSTRACT: Recent epidemics of Zika virus (ZIKV) have been associated with congenital malformation during pregnancy and Guillain-Barré syndrome. There are two ZIKV lineages (African and Asian) that share >95% amino acid identity. Little is known regarding the ability of neutralizing antibodies elicited against one lineage to protect against the other. We investigated the breadth of the neutralizing antibody response following ZIKV infection by measuring the sensitivity of six ZIKV strains to neutralization by ZIKV-confirmed convalescent human serum or plasma samples. Contemporary Asian and early African ZIKV strains were similarly sensitive to neutralization regardless of the cellular source of virus. Furthermore, mouse immune serum generated after infection with African or Asian ZIKV strains was cap

SUBMITTER: Dowd KA 

PROVIDER: S-EPMC5004740 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature