Sensory Response of Transplanted Astrocytes in Adult Mammalian Cortex In Vivo.

ABSTRACT: Glial precursor transplantation provides a potential therapy for brain disorders. Before its clinical application, experimental evidence needs to indicate that engrafted glial cells are functionally incorporated into the existing circuits and become essential partners of neurons for executing fundamental brain functions. While previous experiments supporting for their functional integration have been obtained under in vitro conditions using slice preparations, in vivo evidence for such integration is still lacking. Here, we utilized in vivo two-photon Ca(2+) imaging along with immunohistochemistry, fluorescent indicator labeling-based axon tracing and correlated light/electron microscopy to analyze the profiles and the functional status of glial precursor cell-derived astrocytes in adult m

SUBMITTER: Zhang K 

PROVIDER: S-EPMC5004757 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature