Ontology highlight
ABSTRACT:
SUBMITTER: Larsen JE
PROVIDER: S-EPMC5004933 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Larsen Jill E JE Nathan Vaishnavi V Osborne Jihan K JK Farrow Rebecca K RK Deb Dhruba D Sullivan James P JP Dospoy Patrick D PD Augustyn Alexander A Hight Suzie K SK Sato Mitsuo M Girard Luc L Behrens Carmen C Wistuba Ignacio I II Gazdar Adi F AF Hayward Nicholas K NK Minna John D JD
The Journal of clinical investigation 20160808 9
Increased expression of zinc finger E-box binding homeobox 1 (ZEB1) is associated with tumor grade and metastasis in lung cancer, likely due to its role as a transcription factor in epithelial-to-mesenchymal transition (EMT). Here, we modeled malignant transformation in human bronchial epithelial cells (HBECs) and determined that EMT and ZEB1 expression are early, critical events in lung cancer pathogenesis. Specific oncogenic mutations in TP53 and KRAS were required for HBECs to engage EMT mach ...[more]