Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma.

ABSTRACT:

Background

Immune checkpoint blockade is revolutionizing therapy for advanced cancer, but many patients do not respond to treatment. The identification of robust biomarkers that predict clinical response to specific checkpoint inhibitors is critical in order to stratify patients and to rationally select combinations in the context of an expanding array of therapeutic options.

Methods

We performed multiparameter flow cytometry on freshly isolated metastatic melanoma samples from 2 cohorts of 20 patients each prior to treatment and correlated the subsequent clinical response with the tumor immune phenotype.

Results

Increasing fractions of programmed cell death 1 high/cytotoxic T lymphocyte-associated protein 4 high (PD-1hiCTLA-4hi) cells within the tumor-infiltrating CD

SUBMITTER: Daud AI 

PROVIDER: S-EPMC5004965 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature