Broad autism spectrum and obsessive-compulsive symptoms in adults with the fragile X premutation.

ABSTRACT:

Objective

Clinical observations and a limited number of research studies provide evidence that the fragile X premutation may confer risk for autism, executive dysfunction, and psychopathology. The link to autism spectrum symptoms and social cognition deficits with the premutation remains uncertain, and thus was the focus of the present investigation.

Method

Our sample included 131 individuals, 42 men/22 women with the FMR1 premutation (mean age = 31.83 ± 8.59 years) with a normal neurological exam, and 48 men/19 women healthy age-matched controls (mean age = 29.48 ± 7.29 years). Individuals completed a comprehensive neuropsychological battery with additional assessments for social cognition, broad autism spectrum, and obsessive-compulsive (OC) symptoms.

Results

Premut

SUBMITTER: Schneider A 

PROVIDER: S-EPMC5004987 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature