Analysis of Case-Parent Trios Using a Loglinear Model with Adjustment for Transmission Ratio Distortion.

ABSTRACT: Transmission of the two parental alleles to offspring deviating from the Mendelian ratio is termed Transmission Ratio Distortion (TRD), occurs throughout gametic and embryonic development. TRD has been well-studied in animals, but remains largely unknown in humans. The Transmission Disequilibrium Test (TDT) was first proposed to test for association and linkage in case-trios (affected offspring and parents); adjusting for TRD using control-trios was recommended. However, the TDT does not provide risk parameter estimates for different genetic models. A loglinear model was later proposed to provide child and maternal relative risk (RR) estimates of disease, assuming Mendelian transmission. Results from our simulation study showed that case-trios RR estimates using this model are biased in th

SUBMITTER: Huang LO 

PROVIDER: S-EPMC5005337 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature