Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence.

ABSTRACT: Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging biology that may underlie these diseases is cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes in gene expression, and typically demonstrate altered, pro-inflammatory profiles. Astrocyte senescence has been implicated in neurodegenerative disease, and to better understand senescence-associated changes in astrocytes, we investigated changes in their transcriptome using RNA sequencing. Senescence was induced in human fetal astrocytes by transient oxidative stress. Brain-expressed genes, including those involved in neuronal development and differentiation, were downregulated in senescent astrocytes. Remarkably, several genes indicative of astrocytic responses

SUBMITTER: Crowe EP 

PROVIDER: S-EPMC5005348 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature