The Walker 256 Breast Cancer Cell- Induced Bone Pain Model in Rats.

ABSTRACT: The majority of patients with terminal breast cancer show signs of bone metastasis, the most common cause of pain in cancer. Clinically available drug treatment options for the relief of cancer-associated bone pain are limited due to either inadequate pain relief and/or dose-limiting side-effects. One of the major hurdles in understanding the mechanism by which breast cancer causes pain after metastasis to the bones is the lack of suitable preclinical models. Until the late twentieth century, all animal models of cancer induced bone pain involved systemic injection of cancer cells into animals, which caused severe deterioration of animal health due to widespread metastasis. In this mini-review we have discussed details of a recently developed and highly efficient preclinical model of breas

SUBMITTER: Shenoy PA 

PROVIDER: S-EPMC5005431 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature