Imputing Phenotypes for Genome-wide Association Studies.

ABSTRACT: Genome-wide association studies (GWASs) have been successful in detecting variants correlated with phenotypes of clinical interest. However, the power to detect these variants depends on the number of individuals whose phenotypes are collected, and for phenotypes that are difficult to collect, the sample size might be insufficient to achieve the desired statistical power. The phenotype of interest is often difficult to collect, whereas surrogate phenotypes or related phenotypes are easier to collect and have already been collected in very large samples. This paper demonstrates how we take advantage of these additional related phenotypes to impute the phenotype of interest or target phenotype and then perform association analysis. Our approach leverages the correlation structure between phe

SUBMITTER: Hormozdiari F 

PROVIDER: S-EPMC5005435 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature