Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury.

ABSTRACT:

Unlabelled

The rapid and dynamic transcriptional changes of Schwann cells in response to injury are critical to peripheral nerve repair, yet the epigenomic reprograming that leads to the induction of injury-activated genes has not been characterized. Polycomb Repressive Complex 2 (PRC2) catalyzes the trimethylation of lysine 27 of histone H3 (H3K27me3), which produces a transcriptionally repressive chromatin environment. We find that many promoters and/or gene bodies of injury-activated genes of mature rat nerves are occupied with H3K27me3. In contrast, the majority of distal enhancers that gain H3K27 acetylation after injury are not repressed by H3K27 methylation before injury, which is normally observed in developmentally poised enhancers. Injury induces demethylation of H3K27 in

SUBMITTER: Ma KH 

PROVIDER: S-EPMC5005723 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature