Uncovering Driver DNA Methylation Events in Nonsmoking Early Stage Lung Adenocarcinoma.

ABSTRACT: As smoking rates decrease, proportionally more cases with lung adenocarcinoma occur in never-smokers, while aberrant DNA methylation has been suggested to contribute to the tumorigenesis of lung adenocarcinoma. It is extremely difficult to distinguish which genes play key roles in tumorigenic processes via DNA methylation-mediated gene silencing from a large number of differentially methylated genes. By integrating gene expression and DNA methylation data, a pipeline combined with the differential network analysis is designed to uncover driver methylation genes and responsive modules, which demonstrate distinctive expressions and network topology in tumors with aberrant DNA methylation. Totally, 135 genes are recognized as candidate driver genes in early stage lung adenocarcinoma and top r

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5005773 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature