The rate of metabolism as a factor determining longevity of the Saccharomyces cerevisiae yeast.

ABSTRACT: Despite many controversies, the yeast Saccharomyces cerevisiae continues to be used as a model organism for the study of aging. Numerous theories and hypotheses have been created for several decades, yet basic mechanisms of aging have remained unclear. Therefore, the principal aim of this work is to propose a possible mechanism leading to increased longevity in yeast. In this paper, we suggest for the first time that there is a link between decreased metabolic activity, fertility and longevity expressed as time of life in yeast. Determination of reproductive potential and total lifespan with the use of fob1Δ and sfp1Δ mutants allows us to compare the "longevity" presented as the number of produced daughters with the longevity expressed as the time of life. The results of analyses presented

SUBMITTER: Molon M 

PROVIDER: S-EPMC5005888 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature