Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli.

ABSTRACT: Cellular senescence is a multifactorial phenomenon of growth arrest and distorted function, which has been recognized as an important feature during tumor suppression mechanisms and a contributor to aging. Senescent cells have an altered secretion pattern called Senescence-Associated Secretory Phenotype (SASP) that comprises a complex mix of factors including cytokines, growth factors, chemokines, and matrix metalloproteinases. SASP has been related with local inflammation that leads to cellular transformation and neurodegenerative diseases. Various pathways for senescence induction have been proposed; the most studied is replicative senescence due to telomere attrition called replicative senescence (RS). However, senescence can be prematurely achieved when cells are exposed to diverse sti

SUBMITTER: Maciel-Baron LA 

PROVIDER: S-EPMC5005892 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature