Long-term status and change of body fat distribution, and risk of colorectal cancer: a prospective cohort study.

ABSTRACT:

Background

Although obesity has been linked to an increased risk of colorectal cancer (CRC), the risk associated with long-term status or change of body fat distribution has not been fully elucidated.

Methods

Using repeated anthropometric assessments in the Nurses' Health Study and Health Professionals Follow-up Study, we prospectively investigated cumulative average waist circumference, hip circumference and waist-to-hip ratio, as well as their 10-year changes over adulthood, in relation to CRC risk over 23-24 years of follow-up. Cox proportional hazards models were used to calculate the hazard ratio (HR) and 95% confidence interval (CI).

Results

High waist circumference, hip circumference and waist-to-hip ratio were all associated with a higher CRC risk in men, even

SUBMITTER: Song M 

PROVIDER: S-EPMC5005941 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature