Rapid acquisition of HPV around the time of sexual debut in adolescent girls in Tanzania.

ABSTRACT:

Background

No reports exist on genotype-specific human papillomavirus (HPV) acquisition in girls after first sex in sub-Saharan Africa, despite high HPV prevalence and cervical cancer incidence.

Methods

We followed 503 HP-unvaccinated girls aged 15-16 years in Mwanza, Tanzania, 3-monthly for 18 months with interviews and self-administered vaginal swabs. Swabs were tested for 13 higHRisk and 24 low-risk HPV genotypes. Incidence, clearance and duration of overall HPV and genotype-specific infections were calculated and associated factors evaluated.

Results

A total of 106 participants reported first sex prior to enrolment (N = 29) or during follow-up (N = 77). One was HIV-positive at the final visit. The remaining 105 girls contributed 323 adequate specimens. Incidence o

SUBMITTER: Houlihan CF 

PROVIDER: S-EPMC5005945 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature