The long noncoding RNA ASNR regulates degradation of Bcl-2 mRNA through its interaction with AUF1.

ABSTRACT: The identification and characterization of long non-coding RNAs (lncRNAs) in diverse biological processes has recently developed rapidly. The large amounts of non-coding RNAs scale consistent with developmental complexity in eukaryotes, indicating that most of these transcripts may have functions in the regulation of biological processes and disorder in the organisms. In particular, Understanding of the overall biological significance of lncRNAs in cancers still remains limited. Here, we found a nuclear-retained lncRNA, termed Lnc_ASNR (apoptosis suppressing-noncoding RNA), which serves as a repressor of apoptosis. Lnc_ASNR was discovered in a set of microarray data derived from four kinds of tumor and adjacent normal tissue samples, and displayed significant up-regulation in the tumor tis

SUBMITTER: Chen J 

PROVIDER: S-EPMC5006016 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature