Vascular endothelial growth factor gene polymorphisms and association with age related macular degeneration in Indian patients.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is an important cause of visual impairment in elderly people. AMD is a multifactorial disease in which both environmental and genetic factors have been implicated. Various single nucleotide polymorphisms (SNPs) have been found to be associated with AMD.

Aim

This study was aimed to investigate the association of polymorphisms in VEGF genes with age related macular degeneration (AMD) in Indian patients.

Method

Genotyping for the VEGF - 1154 (G > A), - 2578 (C > A), + 405 (G > C) and - 460 (C > T) SNPs was performed in 100 AMD patients and 100 controls by polymerase chain reaction (PCR), restriction fragment length polymorphism (PCR-RFLP) and sequencing method.

Results

Out of the four SNPs, heterozygous genotypes o

SUBMITTER: Gupta D 

PROVIDER: S-EPMC5006127 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature