Association of adiponectin receptor 1 gene - 106 C > T variant with susceptibility to colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is the fourth leading cause of cancer-related death around the world and accumulated evidence indicates the association between CRC and obesity and insulin resistance.

Objectives

Regarding the role of adiponectin in obesity and insulin resistance, we explored whether genetic variants in adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) are associated with CRC risk.

Materials and methods

ADIPOQ (rs2241766) and ADIPOR1 (rs2275738) gene variants were genotyped in 261 cases with CRC and 339 controls using PCR-RFLP method.

Results

In this study, no significant difference was observed for ADIPOQ gene rs2241766 variant between the cases and controls. However, carriers of the ADIPOR1 (rs2275738) "CC + CT" genotype compared wit

SUBMITTER: Mahmoudi T 

PROVIDER: S-EPMC5006128 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature