Whole-exome sequencing reveals genetic variability among lung cancer cases subphenotyped for emphysema.

ABSTRACT: Lung cancer continues to be a major public health challenge in the United States despite efforts to decrease the prevalence of smoking; outcomes are especially poor for African-American patients compared to other races/ethnicities. Chronic obstructive pulmonary disease (COPD) co-occurs with lung cancer frequently, but not always, suggesting both shared and distinct risk factors for these two diseases. To identify germline genetic variation that distinguishes between lung cancer in the presence and absence of emphysema, we performed whole-exome sequencing on 46 African-American lung cancer cases (23 with and 23 without emphysema frequency matched on age, sex, histology and pack years). Using conditional logistic regression, we found 6305 variants (of 168 150 varying sites) significantly ass

SUBMITTER: Lusk CM 

PROVIDER: S-EPMC5006210 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature