Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI.

ABSTRACT: Despite the significant impact of postoperative delirium on surgical outcomes and the long-term prognosis of older patients, its neural basis has not yet been clarified. In this study we investigated the impact of premorbid brain microstructural integrity, as measured by diffusion tensor imaging before surgery, on postoperative delirium incidence and severity, as well as the relationship among presurgical cognitive performance, diffusion tensor imaging abnormalities and postoperative delirium. Presurgical diffusion tensor imaging scans of 136 older (≥70 years), dementia-free subjects from the prospective Successful Aging after Elective Surgery study were analysed blind to the clinical data and delirium status. Primary outcomes were postoperative delirium incidence and severity during the h

SUBMITTER: Cavallari M 

PROVIDER: S-EPMC5006228 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature