Surface errors without semantic impairment in acquired dyslexia: a voxel-based lesion-symptom mapping study.

ABSTRACT: Patients with surface dyslexia have disproportionate difficulty pronouncing irregularly spelled words (e.g. pint), suggesting impaired use of lexical-semantic information to mediate phonological retrieval. Patients with this deficit also make characteristic 'regularization' errors, in which an irregularly spelled word is mispronounced by incorrect application of regular spelling-sound correspondences (e.g. reading plaid as 'played'), indicating over-reliance on sublexical grapheme-phoneme correspondences. We examined the neuroanatomical correlates of this specific error type in 45 patients with left hemisphere chronic stroke. Voxel-based lesion-symptom mapping showed a strong positive relationship between the rate of regularization errors and damage to the posterior half of the left middle

SUBMITTER: Binder JR 

PROVIDER: S-EPMC5006249 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature