Modulation of gonadotrophin induced steroidogenic enzymes in granulosa cells by d-chiroinositol.

ABSTRACT:

Background

d-chiroinositol (DCI) is a inositolphosphoglycan (IPG) involved in several cellular functions that control the glucose metabolism. DCI functions as second messenger in the insulin signaling pathway and it is considered an insulin sensitizer since deficiency in tissue availability of DCI were shown to cause insulin resistance (IR). Polycystic ovary syndrome (PCOS) is a pathological condition that is often accompanied with insulin resistance. DCI can positively affects several aspect of PCOS etiology decreasing the total and free testosterone, lowering blood pressure, improving the glucose metabolism and increasing the ovulation frequency. The purpose of this study was to evaluate the effects of DCI and insulin combined with gonadotrophins namely follicle-stimulating hormo

SUBMITTER: Sacchi S 

PROVIDER: S-EPMC5006365 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature