Fold-specific sequence scoring improves protein sequence matching.

ABSTRACT:

Background

Sequence matching is extremely important for applications throughout biology, particularly for discovering information such as functional and evolutionary relationships, and also for discriminating between unimportant and disease mutants. At present the functions of a large fraction of genes are unknown; improvements in sequence matching will improve gene annotations. Universal amino acid substitution matrices such as Blosum62 are used to measure sequence similarities and to identify distant homologues, regardless of the structure class. However, such single matrices do not take into account important structural information evident within the different topologies of proteins and treats substitutions within all protein folds identically. Others have suggested that the use

SUBMITTER: Leelananda SP 

PROVIDER: S-EPMC5006591 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature