Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation.

ABSTRACT: Neutrophils are central players in the innate immune system. They generate neutrophil extracellular traps (NETs), which protect against invading pathogens but are also associated with the development of autoimmune and/or inflammatory diseases and thrombosis. Here, we report that lactoferrin, one of the components of NETs, translocated from the cytoplasm to the plasma membrane and markedly suppressed NETs release. Furthermore, exogenous lactoferrin shrunk the chromatin fibers found in released NETs, without affecting the generation of oxygen radicals, but this failed after chemical removal of the positive charge of lactoferrin, suggesting that charge-charge interactions between lactoferrin and NETs were required for this function. In a model of immune complex-induced NET formation in vivo,

SUBMITTER: Okubo K 

PROVIDER: S-EPMC5006695 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature