Preliminary assessment of pre-morbid DNA methylation in individuals at high genetic risk of mood disorders.

ABSTRACT:

Objectives

Accumulating evidence implicates altered DNA methylation in psychiatric disorders, including bipolar disorder (BD) and major depressive disorder (MDD). It is not clear, however, whether these changes are causative or result from illness progression or treatment. To disentangle these possibilities we profiled genome-wide DNA methylation in well, unrelated individuals at high familial risk of mood disorder. DNA methylation was compared between individuals who subsequently developed BD or MDD [ill later (IL)] and those who remained well [well later (WL)].

Methods

DNA methylation profiles were obtained from whole-blood samples from 22 IL and 23 WL individuals using the Infinium HumanMethylation450 BeadChip. Differential methylation was assessed on a single-locus and r

SUBMITTER: Walker RM 

PROVIDER: S-EPMC5006843 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature