Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis.

ABSTRACT:

Background

Quantitative in vivo imaging of myelin loss and repair in patients with multiple sclerosis (MS) is essential to understand the pathogenesis of the disease and to evaluate promyelinating therapies. Selectively binding myelin in the central nervous system white matter, Pittsburgh compound B ([¹¹ C]PiB) can be used as a positron emission tomography (PET) tracer to explore myelin dynamics in MS.

Methods

Patients with active relapsing-remitting MS (n = 20) and healthy controls (n = 8) were included in a longitudinal trial combining PET with [¹¹ C]PiB and magnetic resonance imaging. Voxel-wise maps of [¹¹ C]PiB distribution volume ratio, reflecting myelin content, were derived. Three dynamic indices were calculated for each patient: the

SUBMITTER: Bodini B 

PROVIDER: S-EPMC5006855 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature