Distinct Small RNA Signatures in Extracellular Vesicles Derived from Breast Cancer Cell Lines.

ABSTRACT: Breast cancer is a heterogeneous disease, and different subtypes of breast cancer show distinct cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. Understanding the molecular features responsible for this heterogeneity is important for correct diagnosis and better treatment strategies. Extracellular vesicles (EVs) and their associated molecules have gained much attention as players in intercellular communication, ability to precondition specific organs for metastatic invasion, and for their potential role as circulating cancer biomarkers. EVs are released from the cells and contain proteins, DNA, and long and small RNA species. Here we show by high-throughput small RNA-sequencing that EVs from nine different breast cancer cell lines share c

SUBMITTER: Fiskaa T 

PROVIDER: S-EPMC5006963 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature