A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.

ABSTRACT: Recent studies have shown that a large proportion of patients classified as essential thrombocythemia (ET) actually have early primary prefibrotic myelofibrosis (prePMF), which implies an inferior prognosis as compared to patients being diagnosed with so-called genuine or true ET. According to the World Health Organization (WHO) 2008 classification, bone marrow histology is a major component in the distinction between these disease entities. However, the differential diagnosis between them may be challenging and several studies have not been able to distinguish between them. Most lately, it has been argued that simple blood tests, including the leukocyte count and plasma lactate dehydrogenase (LDH) may be useful tools to separate genuine ET from prePMF, the latter disease entity more often

SUBMITTER: Skov V 

PROVIDER: S-EPMC5007012 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature