Subclinical myocyte injury, fibrosis and strain in relationship to coronary plaque in asymptomatic HIV-infected individuals.

ABSTRACT:

Background

Cardiovascular disease (CVD) rates are increased in HIV. The degree to which myocyte injury, strain, and fibrosis occur prior to clinical disease and relate to coronary plaque in HIV is unknown.

Objective

To investigate newer cardiac biomarkers of subclinical myocyte injury [high-sensitivity troponin T (hs-cTnT)], strain (amino terminal proB-type natriutretic peptide), fibrosis (soluble ST2, Galectin-3), and vascular inflammation (oxidized LDL, lipoprotein-associated phospholipase A2) in HIV-infected individuals and non-HIV controls and relate these to coronary plaque by cardiac computed tomography angiography.

Design

Observational.

Methods

Markers were investigated in 155 HIV-infected and 70 non-HIV-infected participants without known CVD and with l

SUBMITTER: Fitch KV 

PROVIDER: S-EPMC5007151 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature