Genes involved in stress response and alcohol use among high-risk African American youth.

ABSTRACT:

Background

Genetic and environmental factors influence substance use behaviors in youth. One of the known environmental risk factors is exposure to life stressors. The aim of this project is to study the interaction between NR3C1 and CRHBP, genes thought to be involved in stress pathways, exposure to stressful life events, and adolescent alcohol use/misuse.

Methods

The sample included 541 African American individuals (ages 13-18) from the Genes, Environment, and Neighborhood Initiative, a subset of the Mobile Youth Survey sample from whom DNA and more extensive phenotypic data were collected. Participants were selected from high-poverty neighborhoods in Mobile, Alabama, with potential exposure to a variety of extreme life stressors.

Results

A measure of stressful life

SUBMITTER: Goyal N 

PROVIDER: S-EPMC5007209 | biostudies-literature | 2016 Jul-Sep

REPOSITORIES: biostudies-literature