The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner.

ABSTRACT: Memory formation is a complex cognitive function regulated by coordinated synaptic and nuclear processes in neurons. In mammals, it is controlled by multiple molecular activators and suppressors, including the key signalling regulator, protein phosphatase 1 (PP1). Here, we show that memory control by PP1 involves the miR-183/96/182 cluster and its selective regulation during memory formation. Inhibiting nuclear PP1 in the mouse brain, or training on an object recognition task similarly increases miR-183/96/182 expression in the hippocampus. Mimicking this increase by miR-183/96/182 overexpression enhances object memory, while knocking-down endogenous miR-183/96/182 impairs it. This effect involves the modulation of several plasticity-related genes, with HDAC9 identified as an important fun

SUBMITTER: Woldemichael BT 

PROVIDER: S-EPMC5007330 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature