Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders.

ABSTRACT:

Background

Anxiety disorders are common, and cognitive-behavioural therapy (CBT) is a first-line treatment. Candidate gene studies have suggested a genetic basis to treatment response, but findings have been inconsistent.

Aims

To perform the first genome-wide association study (GWAS) of psychological treatment response in children with anxiety disorders (n = 980).

Method

Presence and severity of anxiety was assessed using semi-structured interview at baseline, on completion of treatment (post-treatment), and 3 to 12 months after treatment completion (follow-up). DNA was genotyped using the Illumina Human Core Exome-12v1.0 array. Linear mixed models were used to test associations between genetic variants and response (change in symptom severity) immediately post-treatm

SUBMITTER: Coleman JR 

PROVIDER: S-EPMC5007453 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature