Improved biomechanical and biological outcomes in the MRL/MpJ murine strain following a full-length patellar tendon injury.

ABSTRACT: Musculoskeletal injuries greatly affect the U.S. population and current clinical approaches fail to restore long-term native tissue structure and function. Tissue engineering is a strategy advocated to improve tendon healing; however, the field still needs to establish biological benchmarks for assessing the effectiveness of tissue-engineered structures. Investigating superior healing models, such as the MRL/MpJ, offers the opportunity to first characterize successful healing and then apply experimental findings to tissue-engineered therapies. This study seeks to evaluate the MRL/MpJ's healing response following a central patellar tendon injury compared to wildtype. Gene expression and histology were assessed at 3, 7, and 14 days following injury and mechanical properties were measured at

SUBMITTER: Lalley AL 

PROVIDER: S-EPMC5007538 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature