IBD Genetic Risk Profile in Healthy First-Degree Relatives of Crohn's Disease Patients.

ABSTRACT:

Background

Family history provides important information on risk of developing inflammatory bowel disease [IBD], and genetic profiling of first-degree relatives [FDR] of Crohn's disease [CD]- affected individuals might provide additional information. We aimed to delineate the genetic contribution to the increased IBD susceptibility observed in FDR.

Methods

N = 976 Caucasian, healthy, non-related FDR; n = 4997 independent CD; and n = 5000 healthy controls [HC]; were studied. Genotyping for 158 IBD-associated single nucleotide polymorphisms [SNPs] was performed using the Illumina Immunochip. Risk allele frequency [RAF] differences between FDR and HC cohorts were correlated with those between CD and HC cohorts. CD and IBD genetic risk scores [GRS] were calculated and compared b

SUBMITTER: Kevans D 

PROVIDER: S-EPMC5007582 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature