Plasma Klotho and Cognitive Decline in Older Adults: Findings From the InCHIANTI Study.

ABSTRACT:

Background

The hormone klotho, encoded by the gene klotho, is primarily expressed in the kidney and choroid plexus of the brain. Higher klotho concentrations and certain genetic variants of klotho have been linked to better cognition; however, it is unknown whether klotho relates prospectively to slower cognitive decline in older adults.

Methods

Plasma klotho was measured in 833 participants aged 55 or older without dementia enrolled in InCHIANTI, a prospective cohort study comprising Italian adults. Cognition was measured by Mini-Mental State Examination (MMSE) and Trail-Making Tests A and B (Trails A and Trails B) at enrollment and at 3 and 6 years after enrollment. We assessed whether klotho concentrations measured at the 3-year visit related to cognition and cognitive de

SUBMITTER: Shardell M 

PROVIDER: S-EPMC5007737 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature