Response of Three Different Viruses to Interferon Priming and Dithiothreitol Treatment of Avian Cells.

ABSTRACT:

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We have previously shown that the replication of avian reovirus (ARV) in chicken cells is much more resistant to interferon (IFN) than the replication of vesicular stomatitis virus (VSV) or vaccinia virus (VV). In this study, we have investigated the role that the double-stranded RNA (dsRNA)-activated protein kinase (PKR) plays in the sensitivity of these three viruses toward the antiviral action of chicken interferon. Our data suggest that while interferon priming of avian cells blocks vaccinia virus replication by promoting PKR activation, the replication of vesicular stomatitis virus appears to be blocked at a pretranslational step. Our data further suggest that the replication of avian reovirus in chicken cells is quite resistant to interferon priming because this vi

SUBMITTER: Lostale-Seijo I 

PROVIDER: S-EPMC5008077 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature