Common genetic variation and schizophrenia polygenic risk influence neurocognitive performance in young adulthood.

ABSTRACT: Neurocognitive abilities constitute complex traits with considerable heritability. Impaired neurocognition is typically observed in schizophrenia (SZ), whereas convergent evidence has shown shared genetic determinants between neurocognition and SZ. Here, we report a genome-wide association study (GWAS) on neuropsychological and oculomotor traits, linked to SZ, in a general population sample of healthy young males (n = 1079). Follow-up genotyping was performed in an identically phenotyped internal sample (n = 738) and an independent cohort of young males with comparable neuropsychological measures (n = 825). Heritability estimates were determined based on genome-wide single-nucleotide polymorphisms (SNPs) and potential regulatory effects on gene expression were assessed in human brain. Corr

SUBMITTER: Hatzimanolis A 

PROVIDER: S-EPMC5008149 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature