The artificial pancreas: evaluating risk of hypoglycaemia following errors that can be expected with prolonged at-home use.

ABSTRACT:

Aims

Artificial pancreas systems show benefit in closely monitored at-home studies, but may not have sufficient power to assess safety during infrequent, but expected, system or user errors. The aim of this study was to assess the safety of an artificial pancreas system emulating the β-cell when the glucose value used for control is improperly calibrated and participants forget to administer pre-meal insulin boluses.

Methods

Artificial pancreas control was performed in a clinic research centre on three separate occasions each lasting from 10 p.m. to 2 p.m. Sensor glucose values normally used for artificial pancreas control were replaced with scaled blood glucose values calculated to be 20% lower than, equal to or 33% higher than the true blood glucose. Safe control was defin

SUBMITTER: Wolpert H 

PROVIDER: S-EPMC5008188 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature