Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach.

ABSTRACT: The epithelial to mesenchymal transition (EMT) program is activated in epithelial cancer cells and facilitates their ability to metastasize based on enhanced migratory, proliferative, anti-apoptotic, and pluripotent capacities. Given the fundamental impact of sphingolipid machinery to each individual process, the sphingolipid-related mechanisms might be considered among the most prominent drivers/players of EMT; yet, there is still limited knowledge. Given the complexity of the interconnected sphingolipid system, which includes distinct sphingolipid mediators, their synthesizing enzymes, receptors and transporters, we herein apply an integrative approach for assessment of the sphingolipid-associated mechanisms underlying EMT program. We created the sphingolipid-/EMT-relevant 41-gene/23-gen

SUBMITTER: Meshcheryakova A 

PROVIDER: S-EPMC5008362 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature