Possible role for brain prostanoid pathways in the development of angiotensin II-salt hypertension in rats.

ABSTRACT: Prostanoids generated by the cyclooxygenase (COX) pathway appear to contribute to the neurogenic hypertension (HTN) in rats. The first goal of this study was to establish the time frame during which prostanoids participate in ANG II-salt HTN. We induced HTN using ANG II (150 ng·kg(-1)·min(-1) sc) infusion for 14 days in rats on a high-salt (2% NaCl) diet. When ketoprofen pretreatment was combined with treatment during the first 7 days of ANG II infusion, development of HTN and increased neurogenic pressor activity (indexed by the depressor response to ganglion blockade) were significantly attenuated for the entire ANG II infusion period. This suggests that prostanoid generation caused by administration of ANG II and salt leads to an increase in neurogenic pressor activity and blood pressur

SUBMITTER: Asirvatham-Jeyaraj N 

PROVIDER: S-EPMC5008664 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature