Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment.

ABSTRACT: Malignant tumors are caused by uncontrolled proliferation of transformed mutant cells that have lost the ability to maintain tissue integrity. Although a number of causative genetic backgrounds for tumor development have been discovered, the initial steps mutant cells take to escape tissue integrity and trigger tumorigenesis remain elusive. Here, we show through analysis of conserved neoplastic tumor-suppressor genes (nTSGs) in Drosophila wing imaginal disc epithelia that tumor initiation depends on tissue-intrinsic local cytoarchitectures, causing tumors to consistently originate in a specific region of the tissue. In this "tumor hotspot" where cells constitute a network of robust structures on their basal side, nTSG-deficient cells delaminate from the apical side of the epithelium and be

SUBMITTER: Tamori Y 

PROVIDER: S-EPMC5008749 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature