Genetic risk and longitudinal disease activity in systemic lupus erythematosus using targeted maximum likelihood estimation.

ABSTRACT: Systemic lupus erythematous (SLE) is a chronic autoimmune disease associated with genetic and environmental risk factors. However, the extent to which genetic risk is causally associated with disease activity is unknown. We utilized longitudinal-targeted maximum likelihood estimation to estimate the causal association between a genetic risk score (GRS) comprising 41 established SLE variants and clinically important disease activity as measured by the validated Systemic Lupus Activity Questionnaire (SLAQ) in a multiethnic cohort of 942 individuals with SLE. We did not find evidence of a clinically important SLAQ score difference (>4.0) for individuals with a high GRS compared with those with a low GRS across nine time points after controlling for sex, ancestry, renal status, dialysis, disea

SUBMITTER: Gianfrancesco MA 

PROVIDER: S-EPMC5008986 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature