Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders.

ABSTRACT:

Background

Schizophrenia is associated with cognitive impairment and brain network dysconnectivity. Recent efforts have explored brain circuits underlying cognitive dysfunction in schizophrenia and documented altered activation of large-scale brain networks, including the task-positive network (TPN) and the task-negative default mode network (DMN) in response to cognitive demands. However, to what extent TPN and DMN dysfunction reflect overlapping mechanisms and are dependent on cognitive state remain to be determined.

Methods

In the current study, we investigated the recruitment of TPN and DMN using independent component analysis in patients with schizophrenia spectrum disorders (n = 29) and healthy controls (n = 21) during two different executive tasks probing planning/pro

SUBMITTER: Haatveit B 

PROVIDER: S-EPMC5009228 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature