The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.

ABSTRACT: Aggregates of abnormal proteins are widely observed in neuronal and glial cells of patients with various neurodegenerative diseases, and it has been proposed that prion-like behavior of these proteins can account for not only the onset but also the progression of these diseases. However, it is not yet clear which abnormal protein structures function most efficiently as seeds for prion-like propagation. In this study, we aimed to identify the most pathogenic species of α-synuclein (α-syn), the main component of the Lewy bodies and Lewy neurites that are observed in α-synucleinopathies. We prepared various forms of α-syn protein and examined their seeding properties in vitro in cells and in mouse experimental models. We also characterized these α-syn species by means of electron microscopy a

SUBMITTER: Tarutani A 

PROVIDER: S-EPMC5009244 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature