A path-based measurement for human miRNA functional similarities using miRNA-disease associations.

ABSTRACT: Compared with the sequence and expression similarity, miRNA functional similarity is so important for biology researches and many applications such as miRNA clustering, miRNA function prediction, miRNA synergism identification and disease miRNA prioritization. However, the existing methods always utilized the predicted miRNA target which has high false positive and false negative to calculate the miRNA functional similarity. Meanwhile, it is difficult to achieve high reliability of miRNA functional similarity with miRNA-disease associations. Therefore, it is increasingly needed to improve the measurement of miRNA functional similarity. In this study, we develop a novel path-based calculation method of miRNA functional similarity based on miRNA-disease associations, called MFSP. Compared wi

SUBMITTER: Ding P 

PROVIDER: S-EPMC5009308 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature