Distinct metabolic network states manifest in the gene expression profiles of pediatric inflammatory bowel disease patients and controls.

ABSTRACT: Information on biological networks can greatly facilitate the function-orientated interpretation of high-throughput molecular data. Genome-wide metabolic network models of human cells, in particular, can be employed to contextualize gene expression profiles of patients with the goal of both, a better understanding of individual etiologies and an educated reclassification of (clinically defined) phenotypes. We analyzed publicly available expression profiles of intestinal tissues from treatment-naive pediatric inflammatory bowel disease (IBD) patients and age-matched control individuals, using a reaction-centric metabolic network derived from the Recon2 model. By way of defining a measure of 'coherence', we quantified how well individual patterns of expression changes matched the metabolic n

SUBMITTER: Knecht C 

PROVIDER: S-EPMC5009330 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature