Trajectories of functional decline in knee osteoarthritis: the Osteoarthritis Initiative.

ABSTRACT:

Objective

To describe trajectories of functional decline over 84 months and study associated risk factors among adults initially without limitation who had or were at risk of knee OA.

Methods

We used annual measures of WOMAC physical function over 84 months from the OA Initiative. We included knees with no functional limitation (i.e. WOMAC = 0) at baseline. Knee-based trajectories of functional decline from WOMAC were identified from a group-based trajectory model (PROC TRAJ).

Results

We identified five trajectories from 2110 knees (1055 participants, age 61.0 ± 9.3, BMI 27.1 ± 4.4, 52% women). Half of the knees (54%) remained free of limitation over 84 months, 26% slowly declined to a WOMAC of 1.5, 9% were limitation free for the first 36 months and declined to a WOM

SUBMITTER: White DK 

PROVIDER: S-EPMC5009418 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature