Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis.

ABSTRACT:

Objectives

Neutrophil elastase (NE), a granule-associated enzyme, participates in connective tissue breakdown and promotes cytokine release and specific receptor activation during various inflammatory diseases like RA. NE is increased in the SF and cartilage of RA patients and represents a target for the development of new therapeutic possibilities. The present research aimed to evaluate the preclinical pharmacological profile of the N-benzoylpyrazole derivative EL-17, a potent and selective NE inhibitor, in a rat model of RA.

Methods

Complete Freund's Adjuvant (CFA) was injected in the tibiotarsal joint and the effect of acute or repeated treatments with EL-17 (1-30 mg/kg by mouth) were evaluated.

Results

On day 14 after CFA injection, a single administration of EL-1

SUBMITTER: Di Cesare Mannelli L 

PROVIDER: S-EPMC5009473 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature